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The agency urges consumers who are using quinine products and have questions or concerns to contact their health care provider. These drugs may increase the risk of hypoglycemia by enhancing insulin sensitivity (ACE inhibitors, fibrates, ginseng); stimulating insulin secretion (salicylates, disopyramide, quinine, quinidine, MAOIs, ginseng); increasing peripheral glucose utilization (SSRIs, insulin-like growth factor); inhibiting gluconeogenesis (SSRIs, MAOIs, insulin-like growth factor); slowing the rate of gastric emptying (amylin analogs); and/or suppressing postprandial glucagon secretion (amylin analogs). A manufacturer of a formerly available quinine product considered it contraindicated in pregnancy. Unlike the approved product, many unapproved quinine drug products are marketed without labeling cautioning against use of the product for treatment of leg cramps. quinine food/lifestyle InteractionsThere is 1 food/lifestyle interaction with quinineSee also. Quinine is approved for treatment of malaria, but is also commonly prescribed to treat leg cramps and similar conditions. In doses several times higher than those used to treat malaria, quinine may stimulate the pregnant uterus. I drink a glass of club soda with quinine in it. Although increased teratogenic risk has not been proven, avoiding quinine use during pregnancy has been recommended. Because malaria is life-threatening, the risks associated with quinine use are justified for that condition.

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